How to solve the problem of residual air in prefilled syringes

Update:11 Mar 2021

The use of prefilled syringes is very common, and the p […]

The use of prefilled syringes is very common, and the prefilled syringes have very good stability, so the market potential is huge, and they are deeply loved by the majority of users!

It is impossible to produce prefilled syringes without air bubbles, even under the lowest vacuum, there will still be some air molecules remaining in the syringe. If the best process conditions are used, the bubbles may be so small that they are invisible to the naked eye. The size of the remaining bubbles mainly depends on the vacuum in the syringe and the filling level during operation. The amount of dissolved gas is negligible, such as using a traditional vacuum

Plugging method: Filling a 1ml (long) syringe with 0.75ml of water-based product and pressing the plug at a pressure of 100mbar will generate bubbles with a diameter of 2mm (based on a pressure of 1000mbar).

As the gas is dissolved in the product, the volume of bubbles can be reduced by about 10%. Generally speaking, the pressure in the syringe must be significantly higher than the vapor pressure of the product. Low vacuum, low friction, high filling level, high gas solubility, and the use of push rods will reduce the residual gas space in the syringe.

Nutrient cream pre-filling is also called a perfusion device. It is usually composed of a tube sleeve, push rod, piston, positioning ring and protective cap. This product can be used as a medicine package or as a syringe, which not only saves the cost of pharmaceutical manufacturers, but also And improve the efficiency of use.

Nutrient paste pre-filling is mainly divided into cone head type and spiral head type. The cone head type is composed of a tube sleeve, a cone head cap, a piston and a push rod; the spiral head type is composed of a glass needle tube, a spiral head cap, and a spiral head. Composed of piston and push rod.

Filling process of prefilled syringe:

A semi-automatic filling machine is used to fill a certain amount of medicine in a glass needle tube (with a protective cap), press or screw in the piston to seal the liquid medicine, and then install a push rod for packaging.

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