Significance of detecting piston sliding property of prefilled syringe

Update:20 Oct 2020
Summary:

The increasing use of prefilled syringes has attracted […]

The increasing use of prefilled syringes has attracted more and more manufacturers and prompted them to optimize production processes to improve production efficiency and reduce production costs; however, under the premise of rapid development, we must also pay attention to prefilled syringes. Product quality.

Pre-filled syringes are widely used because of their convenient and quick use, no pollution in the whole process, and cost saving. Manufacturers are also paying attention to the physical testing indicators of prefilled syringes while continuously improving processes and increasing production efficiency.

The slidability of the rubber piston of the prefilled syringe is one of them. The piston uses the push rod to generate resistance during the travel of the inner wall of the glass needle tube. It is detected that it is used to push the push rod and use a certain speed (dose speed) to push the piston to the needle tube. The force value produced during the bottom stop (dose completion). In actual use, if the force is too large, it will cause difficulty in injection, and if the force is too small, the injection will be too fast or too strong and cause danger.

 

The infusion device is a new type of medicine packaging container with high technical content and suitable for injection and injection dosage forms. The syringe and the liquid medicine packaging container are combined into one, and the injection is directly in use, which is very convenient. There are strict requirements for the decolorization of the infusion device. The main test methods and requirements are as follows:

Decolorization experiment of perfusion device:

Take three groups of 4g test bottles, cut into small pieces of 2.0×0.3 cm, and place them in 3 conical flasks with stoppers. Add 4% acetic acid solution (60℃±2℃, 2 hours) and 65% ethanol solution respectively. (25℃±2℃, 2 hours), immerse in 50 ml of n-hexane (25℃±2℃, 2 hours), use the same batch of 4% acetic acid solution, 65% ethanol solution, and n-hexane as blank solutions. Deeper than blank solution. White bottles are not subject to this inspection.

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